Topical delivery of clobetasole propionate (CP) offers several formulation related problems due to poor water solubility and photo degradation property. In the present investigation, topical gel of CP was formulated using acrylamide/ sodium acryloyldimethyl taurate copolymer (SEPINEOââ??¢ P 600) as a gelling agent and evaluated with respect to different physicochemical parameters such as pH, viscosity, bio-adhesivity, spreadability, in-vitro drug release and photo stability. Permeation of CP gel was studied using freshly excised pig ear skin for 24 h. The cumulative permeation of drug through excised rat skin was 3.0Ã?±1.2 mg cm-2 with the corresponding flux value of 0.24Ã?±0.09 mg cm-2 h-1. The in-vitro release studies showed 101.43Ã?±1.12 % drug release over 10 h. The selected formulation was found to be effective with respect to percent drug content, permeation characteristics, pH, viscosity and photostability. Therefore, CP gel could be very promising alternative for the topical drug delivery.
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